Elena Aikawa Selected Research

Calcinosis

1/2022	Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.
1/2021	Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
1/2021	2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
1/2020	S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
1/2020	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
1/2019	18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
1/2019	Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
5/2018	Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
3/2017	Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
4/2016	Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

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Elena Aikawa Research Topics

Disease

33	Atherosclerosis 01/2021 - 10/2005
26	Inflammation (Inflammations) 01/2022 - 07/2006
19	Atherosclerotic Plaque (Atheroma) 01/2021 - 10/2005
14	Calcinosis 01/2022 - 06/2013
13	Cardiovascular Diseases (Cardiovascular Disease) 12/2022 - 03/2013
11	Aortic Valve Disease 12/2022 - 01/2007
9	Myocardial Infarction 01/2022 - 04/2007
9	Vascular Calcification 01/2021 - 03/2012
8	Chronic Renal Insufficiency 01/2017 - 04/2009
5	Aortic Valve Stenosis (Aortic Stenosis) 01/2021 - 01/2007
4	Rupture 01/2021 - 11/2011
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 07/2017
4	Disease Progression 01/2019 - 04/2009
4	Fibrosis (Cirrhosis) 01/2018 - 09/2007
3	Neoplasms (Cancer) 12/2021 - 04/2009
3	Neointima 10/2021 - 09/2007
3	Heart Failure 10/2015 - 02/2008
3	Infarction (Infarctions) 04/2010 - 02/2008
2	Left Ventricular Outflow Obstruction 12/2022 - 12/2015
2	Arteritis 10/2021 - 01/2015
2	Obesity 01/2021 - 01/2018
2	Diabetes Mellitus 01/2018 - 12/2011
2	Thrombosis (Thrombus) 07/2017 - 06/2017
2	Ventricular Remodeling 01/2016 - 07/2009
2	Vascular Diseases (Vascular Disease) 01/2016 - 02/2013
2	Stroke (Strokes) 10/2015 - 11/2008
2	Necrosis 11/2011 - 11/2009
2	Hypercholesterolemia 10/2010 - 01/2007
1	COVID-19 01/2022
1	Heart Valve Diseases (Valvular Heart Disease) 01/2022
1	Hyperplasia 10/2021

Drug/Important Bio-Agent (IBA)

14	CollagenIBA 01/2021 - 10/2005
11	ApolipoproteinsIBA 01/2021 - 10/2005
11	Apolipoproteins E (ApoE)IBA 01/2021 - 10/2005
8	Pharmaceutical PreparationsIBA 01/2022 - 04/2009
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 11/2008
7	MineralsIBA 01/2021 - 08/2010
6	LipidsIBA 12/2022 - 05/2011
6	HydrogelsIBA 01/2022 - 03/2016
6	CholesterolIBA 01/2021 - 07/2006
6	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 04/2007
5	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2022 - 01/2007
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2011
5	Lipoprotein(a)IBA 01/2022 - 08/2015
5	Small Interfering RNA (siRNA)IBA 01/2021 - 04/2015
5	Messenger RNA (mRNA)IBA 01/2018 - 10/2009
5	sortilinIBA 01/2018 - 04/2016
5	EnzymesIBA 01/2012 - 02/2008
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 11/2008
4	MicroRNAs (MicroRNA)IBA 12/2021 - 03/2013
4	Phenobarbital (Luminal)FDA Link 07/2017 - 09/2007
4	Peroxidase (Myeloperoxidase)IBA 01/2012 - 03/2008
4	Collagenases (Collagenase)FDA Link 11/2011 - 10/2005
4	Matrix Metalloproteinases (MMPs)IBA 10/2010 - 10/2005
3	LDL CholesterolIBA 12/2022 - 03/2012
3	CalciumIBA 12/2022 - 01/2017
3	CytokinesIBA 01/2022 - 01/2020
3	Collagen Type I (Type I Collagen)IBA 01/2022 - 11/2011
3	LDL Receptors (LDL Receptor)IBA 01/2019 - 03/2012
3	Alkaline PhosphataseIBA 01/2018 - 04/2015
3	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 09/2017 - 10/2006
3	cathepsin SIBA 01/2017 - 04/2009
3	Cysteine Proteases (Cysteine Protease)IBA 01/2017 - 05/2007
3	oxidized low density lipoproteinIBA 03/2012 - 10/2009
3	Gadolinium DTPA (Magnevist)FDA Link 01/2012 - 03/2008
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022 - 01/2019
2	N 30IBA 01/2022 - 01/2007
2	(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA 10/2021 - 01/2021
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 10/2021 - 07/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2021
2	Apolipoprotein C-IIIIBA 01/2021 - 01/2020
2	ElementsIBA 01/2021 - 03/2016
2	ProteomeIBA 01/2021 - 01/2018
2	Lipid NanoparticlesIBA 01/2020 - 01/2019
2	Phosphates (Orthophosphate)IBA 01/2019 - 01/2017
2	LigandsIBA 01/2019 - 07/2012
2	salicylhydroxamic acid (SHAM)IBA 09/2017 - 01/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2017 - 12/2015
2	Annexin A5IBA 03/2017 - 06/2013
2	Biological ProductsIBA 12/2015 - 07/2009
2	Cathepsin KIBA 04/2015 - 05/2007
2	Matrix Metalloproteinase 13IBA 11/2011 - 10/2005
2	Indocyanine Green (Cardio-Green)FDA LinkGeneric 05/2011 - 03/2006
2	GadoliniumIBA 11/2009 - 11/2008
1	WD repeat containing planar cell polarity effectorIBA 01/2022
1	Estrogen Receptor alphaIBA 01/2022
1	prothymosin alphaIBA 01/2022
1	MetalsIBA 10/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2021
1	Differentiation AntigensIBA 10/2021
1	CalponinsIBA 10/2021
1	4- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)IBA 01/2021
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2021

Therapy/Procedure

16	Therapeutics 12/2022 - 07/2006
3	Drug Therapy (Chemotherapy) 01/2021 - 10/2006
2	Ligation 01/2016 - 10/2009
2	Lasers (Laser) 04/2015 - 03/2006
1	Secondary Prevention 12/2022
1	Stents 10/2021